August 13, 2022 (Saturday) 7 p.m. Away ULM (exhibition) Monroe, LA W, 2-0
August 15, 2022 (Monday) 7 p.m. Away East Texas Baptist (exhibition) Marshall, Texas
August 18, 2022 (Thursday) 7 p.m. Home Murray State Ruston, LA / Robert Mack Caruthers Field CUSA.tv Postponed
August 19, 2022 (Friday) 11 a.m. Home Murray State Ruston, La / Robert Mack Caruthers Field CUSA.TV W, 2-1
August 21, 2022 (Sunday) 1 p.m. Home Northwestern State Ruston, LA / Robert Mack Caruthers Field CUSA.TV L, 1-4
August 26, 2022 (Friday) 7 p.m. Home Abilene Christian Ruston, LA / Robert Mack Caruthers Field Cusa.tv W, 1-0
August 28, 2022 (Sunday) 1 p.m. Home UL-Lafayette Ruston, LA / Robert Mack Caruthers Field Cusa.tv T, 0-0
September 1, 2022 (Thursday) 6 p.m. Away Ole Miss Oxford, Miss. SEC Network +
September 4, 2022 (Sunday) 1 p.m. Away Mississippi State Starkville, Miss. SEC Network +
September 6, 2022 (Tuesday) 6:30 p.m. Away Sam Houston Huntsville, Texas ESPN +
September 9, 2022 (Friday) 6 p.m. Away Little Rock Little Rock, Ark. ESPN+
September 15, 2022 (Thursday) 7 p.m. Home WKU Ruston, LA / Robert Mack Caruthers Field Cusa.tv
September 18, 2022 (Sunday) 2 p.m. Away UTEP El Paso, Texas Cusa.tv
September 22, 2022 (Thursday) 6 p.m. Away Charlotte Charlotte, N.C. ESPN+
September 25, 2022 (Sunday) 1 p.m. Home Rice Ruston, LA / Robert Mack Caruthers Field cusa.tv
October 2, 2022 (Sunday) 1 p.m. Home FIU Ruston, LA / Robert Mack Caruthers Field cusa.tv
October 6, 2022 (Thursday) 7 p.m. Home UTSA Ruston, LA / Robert Mack Caruthers Field cusa.tv
October 9, 2022 (Sunday) 1 p.m. Away Middle Tennessee Murfreesboro, Tenn.
October 16, 2022 (Sunday) Noon Away Florida Atlantic Boca Raton, FL
October 23, 2022 (Sunday) 1 p.m. Home UAB Ruston, LA / Robert Mack Caruthers Field cusa.tv
October 29, 2022 (Saturday) 7 p.m. Away North Texas Denton, Texas ESPN+
October 31, 2022 (Monday) TBA Neutral C-USA Tournament Charlotte, N.C. C-USA Tournament