Here is how I picked against last year. I try to avoid picking against teams with Zero wins. They sometimes burn you. Look at Detroit vs. Washing (albeit Washington is not a good team).

Cincy x 3
Cleveland x 1
Detroit x 2 (I didn't want to get burned)
KC x 1
Miami x 2 (didn't pick'em again after beating NE)
Oakland x 3
Seattle x 1
St. Louis x 2